id,agency_id,docket_id,title,document_type,subtype,posted_date,posted_year,posted_month,comment_start_date,comment_end_date,last_modified,fr_doc_num,open_for_comment,withdrawn,object_id
FDA-2016-N-3389-0394,FDA,FDA-2016-N-3389,Request to Extend Comment Period from Grocery Manufacturers Association,Other,Electronic Regulation from Form,2016-12-29T05:00:00Z,2016,12,2016-12-29T05:00:00Z,,2016-12-29T17:19:26Z,,0,0,0900006482432fb6
FDA-2016-N-3389-0008,FDA,FDA-2016-N-3389,"Reference 02-05 Evaluation of satiety enhancement, including  compensation, by blends of gum arabic. A methodological approach re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T17:52:51Z,,0,0,090000648239903a
FDA-2016-N-3389-0023,FDA,FDA-2016-N-3389,"Reference 02-20 In vivo imaging of intragastric and its effect on satiety in humans re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T17:57:02Z,,0,0,09000064823990d7
FDA-2016-N-3389-0151,FDA,FDA-2016-N-3389,"Reference 02-148 Effects of consumption a bread contains agave or chicory inulin on lipids and blood pressure in patients with cardiovascular risk factors re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:17:56Z,,0,0,09000064823996bd
FDA-2016-N-3389-0154,FDA,FDA-2016-N-3389,"Reference 02-151 Inulin and oligofructose What are they re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:18:36Z,,0,0,09000064823996c2
FDA-2016-N-3389-0158,FDA,FDA-2016-N-3389,"Reference 02-155 Gut hormone release and appetite regulation in healthy non-obese participants following oligofructose intake A dose-escalation study re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:19:10Z,,0,0,09000064823996ef
FDA-2016-N-3389-0189,FDA,FDA-2016-N-3389,"Reference 02-186 Microbiota benefits after inulin and partially hydrolized guar gum supplementation – a randomized clinical trial in constipated women re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:24:44Z,,0,0,0900006482399739
FDA-2016-N-3389-0330,FDA,FDA-2016-N-3389,"Reference 02-328 Suppressive effect of resistant maltodextrin on postprandial blood triglycerol elevation re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:46:42Z,,0,0,090000648239986a
FDA-2016-N-3389-0343,FDA,FDA-2016-N-3389,"Reference 02-342 A double-blind placebo-controlled clinical trial compares the cholesterol lowering effects of two different soy protein preparations re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:48:15Z,,0,0,090000648239989c
FDA-2016-N-3389-0350,FDA,FDA-2016-N-3389,"Reference 02-349 Effects of some cereal brans and textured vegetable protein on plasma lipids re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:48:59Z,,0,0,09000064823998b4
FDA-2016-N-3389-0120,FDA,FDA-2016-N-3389,"Reference 02-117 Acute effects of a herb extract formulation and inulin fibre on appetite, energy intake and food choice re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:14:07Z,,0,0,0900006482399943
FDA-2016-N-3389-0050,FDA,FDA-2016-N-3389,"Reference 02-46 Alteration of the fiber and lipid components of a defined-formula diet effects on stool characteristics, nutrient digestibility, mineral balance re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:02:34Z,,0,0,0900006482399510
FDA-2016-N-3389-0111,FDA,FDA-2016-N-3389,"Reference 02-108 Effect of inulin and fructo-oligosaccharide on the prevention of acute radiation enteritis in patients with gynecological cancer and impact on quality-of-life re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:13:11Z,,0,0,090000648239964b
FDA-2016-N-3389-0213,FDA,FDA-2016-N-3389,"Reference  02-209 Long-term blood cholesterol-lowering effects of a dietary fiber supplement re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:28:32Z,,0,0,09000064823999f6
FDA-2016-N-3389-0215,FDA,FDA-2016-N-3389,"Reference  02-211 Decreased postprandial thermogenesis and fat oxidation but increased fullness after a high-fiber meal compared with a low-fiber meal re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:28:52Z,,0,0,09000064823999f8
FDA-2016-N-3389-0238,FDA,FDA-2016-N-3389,"Reference 02-235 Volume of food consumed affect satiety in men re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:32:49Z,,0,0,0900006482399a31
FDA-2016-N-3389-0242,FDA,FDA-2016-N-3389,"Reference 02-239 Attenuated response of the serum triglyceride concentration to ingestion of a chocolate containing polydextrose and lactitol in place of sugar re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:33:24Z,,0,0,0900006482399a35
FDA-2016-N-3389-0259,FDA,FDA-2016-N-3389,"Reference 02-256 Effect of carbohydrate digestibility on appetite and its relationship to postprandial blood glucose and insulin levels re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:36:16Z,,0,0,0900006482399a66
FDA-2016-N-3389-0272,FDA,FDA-2016-N-3389,"Reference 02-269 Acute ingestion of resistant starch reduces food intake in healthy adults re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:38:48Z,,0,0,0900006482399a97
FDA-2016-N-3389-0276,FDA,FDA-2016-N-3389,"Reference 02-273  Interaction between physical structure and amyloseamylopectin ratio of foods on postprandial glucose and insulin responses in healthy subjects re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:39:16Z,,0,0,0900006482399a9b
FDA-2016-N-3389-0227,FDA,FDA-2016-N-3389,"Reference 02-224 Effects of polydextrose supplementation on different faecal parameters in healthy volunteers re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:30:30Z,,0,0,0900006482399790
FDA-2016-N-3389-0266,FDA,FDA-2016-N-3389,"Reference 02-263 Effect of long-term consumption of amylose vs amylopectin starch on metabolic variables in human subjects re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:37:50Z,,0,0,09000064823997db
FDA-2016-N-3389-0308,FDA,FDA-2016-N-3389,"Reference 02-305 Design criteria for studies examining individual fatty acid effects on cardiovascular disease risk factors human and animal studies re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:43:49Z,,0,0,0900006482399827
FDA-2016-N-3389-0304,FDA,FDA-2016-N-3389,"Reference 02-301 Physiological effects of resistant starches on fecal bulk, short chain fatty acids, blood lipids and glycemic index re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:43:19Z,,0,0,0900006482399ad7
FDA-2016-N-3389-0367,FDA,FDA-2016-N-3389,"Reference 02-366 Serum lipid and fecal bile acid changes with cereal, vegetable, and sugar-beet fiber feeding re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:51:48Z,,0,0,0900006482399bb2
FDA-2016-N-3389-0372,FDA,FDA-2016-N-3389,"Reference 02-371 The effects of two dietary fiber supplements on gastrointestinal transit, stool weight and frequency re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:53:25Z,,0,0,0900006482399bb7
FDA-2016-N-3389-0018,FDA,FDA-2016-N-3389,"Reference 02-15 Fiber and prebiotics mechanism and health benefits re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T17:56:23Z,,0,0,09000064823990d2
FDA-2016-N-3389-0021,FDA,FDA-2016-N-3389,"Reference 02-18 Ascophyllum nodosum enriched bread reduces subsequent energy intake with no effect on post-prandial glucose and cholesterol in healthy, overweight males re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T17:56:47Z,,0,0,09000064823990d5
FDA-2016-N-3389-0024,FDA,FDA-2016-N-3389,"Reference 02-21 Can alginate-based preloads increase weight loss beyond calorie restriction A pilot study in obese individuals re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T17:57:08Z,,0,0,09000064823990d8
FDA-2016-N-3389-0036,FDA,FDA-2016-N-3389,"02-33 Differences in satiety effects of alginate- and whey protein-based foods re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T17:59:04Z,,0,0,09000064823990f2
FDA-2016-N-3389-0039,FDA,FDA-2016-N-3389,"02-35 The effects of bulking, viscous and gel-forming dietary fibres on satiation re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:00:20Z,,0,0,09000064823990f5
FDA-2016-N-3389-0011,FDA,FDA-2016-N-3389,"Reference 02-08 Role of water-soluble dietary fiber in the management of elevated plasma cholesterol in healthy subjects re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T17:53:16Z,,0,0,09000064823993af
FDA-2016-N-3389-0028,FDA,FDA-2016-N-3389,"Reference 02-25 Effect of sodium alginate addition to chocolate milk on  glycemia, insulin, appetite and food intake in healthy adult men re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T17:57:38Z,,0,0,09000064823993eb
FDA-2016-N-3389-0033,FDA,FDA-2016-N-3389,"Reference 02-30 Daily ingestion of alginate reduces energy intake in free-living subjects re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T17:58:12Z,,0,0,09000064823993f0
FDA-2016-N-3389-0100,FDA,FDA-2016-N-3389,"Reference 02-96 Inulin controls inflammation and metabolic endotoxemia in women with type 2 diabetes mellitus a randomized-controlled clinical trial re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:09:26Z,,0,0,09000064823994e2
FDA-2016-N-3389-0135,FDA,FDA-2016-N-3389,"Reference 02-132 Effects of inulin and lactose on fecal microflora, microbial activity, and bowel habit in elderly constipated persons re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:15:40Z,,0,0,0900006482399695
FDA-2016-N-3389-0137,FDA,FDA-2016-N-3389,"Reference 02-134 Effects of inulin on faecal bifidobacteria in human subjects re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:16:03Z,,0,0,0900006482399697
FDA-2016-N-3389-0334,FDA,FDA-2016-N-3389,"Reference 02-332 Design criteria for studies examining individual fatty acid effects on cardiovascular disease risk factors human and animal studies re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:47:08Z,,0,0,0900006482399882
FDA-2016-N-3389-0346,FDA,FDA-2016-N-3389,"Reference 02-345 Effect of soya and cellulose fibers on postprandial glycemic response in type II diabetic patients re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:48:34Z,,0,0,090000648239989f
FDA-2016-N-3389-0356,FDA,FDA-2016-N-3389,"Reference 02-355 Effects of soy polysaccharide on postprandial plasma glucose, insulin, glucagon, pancreatic polypeptide, somatostatin, and triglyceride in obese diabetic patients re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:50:32Z,,0,0,09000064823998ba
FDA-2016-N-3389-0363,FDA,FDA-2016-N-3389,"Reference 02-362 Reduced glycemic response to beet-fibre meal in non-insulin-dependent diabetics and its relation to plasma levels of pancreatic and gastrointestinal hormones re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:51:18Z,,0,0,09000064823998d1
FDA-2016-N-3389-0178,FDA,FDA-2016-N-3389,"Reference 02-175 Chicory inulin does not increase stool weight or speed up intestinal transit time in healthy male subjects re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:23:09Z,,0,0,0900006482399994
FDA-2016-N-3389-0381,FDA,FDA-2016-N-3389,"Reference 02-380 Metabolic characteristics of healthy adult males as affected by ingestion of a liquid nutritional formula re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:57:36Z,,0,0,0900006482399bc9
FDA-2016-N-3389-0001,FDA,FDA-2016-N-3389,"Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Notice,Request for Comments,2016-11-23T05:00:00Z,2016,11,2016-11-23T05:00:00Z,2017-01-10T04:59:59Z,2017-01-13T02:00:53Z,2016-27950,0,0,09000064823b9adb
FDA-2016-N-3389-0114,FDA,FDA-2016-N-3389,"Reference 02-111 Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:13:31Z,,0,0,0900006482399900
FDA-2016-N-3389-0115,FDA,FDA-2016-N-3389,"Reference 02-112 Prebiotics consumption modifies diastolic blood pressure, but does not affect serum lipids concentratoin in volunteers with ischemic heart disease re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:13:38Z,,0,0,0900006482399901
FDA-2016-N-3389-0144,FDA,FDA-2016-N-3389,"Reference 02-141 Fructooligosaccharide (FOS) supplementation in type 2 diabetic adults improves systolic blood pressure, serum lipid, and gut microbiota re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:16:54Z,,0,0,090000648239995d
FDA-2016-N-3389-0163,FDA,FDA-2016-N-3389,"Reference 02-160 Effects of oligofructose-enriched inulin prebiotic supplementation on the lipid profile and inflammation in women with type 2 diabetes re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:20:49Z,,0,0,0900006482399976
FDA-2016-N-3389-0080,FDA,FDA-2016-N-3389,"Reference 02-76 Metabolic characteristics of healthy adult males as affected by ingestion of a liquid nutritional formula containing fish oil, oligosaccharides, gum Arabic re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:07:03Z,,0,0,0900006482399563
FDA-2016-N-3389-0093,FDA,FDA-2016-N-3389,"Reference 02-89 Consuming foods with added oligofructose improves stool frequency a randomized trial in healthy young adults re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:08:39Z,,0,0,090000648239958d
FDA-2016-N-3389-0107,FDA,FDA-2016-N-3389,"Reference 02-103 GRAS Notification 44 re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:10:56Z,,0,0,09000064823995af
FDA-2016-N-3389-0110,FDA,FDA-2016-N-3389,"Reference 02-107 Tolerance and the effect of high doses of wheat bran extract, containing arabinoxylan-oligosaccharides, and oligofructose on faecal output re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:11:22Z,,0,0,090000648239964a
FDA-2016-N-3389-0247,FDA,FDA-2016-N-3389,"Reference 02-244 Glycemic responses to sweetened dried and raw cranberries in human with type 2 diabetes re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:34:09Z,,0,0,0900006482399a4a
FDA-2016-N-3389-0220,FDA,FDA-2016-N-3389,"Reference 02-217 Snacks containing whey protein and polydextrose induce a sustained reduction in daily energy intake over 2 wk under free-living conditions re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:29:37Z,,0,0,0900006482399789
FDA-2016-N-3389-0223,FDA,FDA-2016-N-3389,"Reference 02-220 The effects of oligofructose and polydextrose on metabolic control parameters in type-2 diabetes re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:29:57Z,,0,0,090000648239978c
FDA-2016-N-3389-0228,FDA,FDA-2016-N-3389,"Reference 02-225 Consuming polydextrose in a mid-morning snack increases acute satiety measurements and reduces subsequent energy intake at lunch in healthy human subjects re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:30:38Z,,0,0,0900006482399791
FDA-2016-N-3389-0322,FDA,FDA-2016-N-3389,"Reference 02-319 Fermentable fibers do not affect satiety or food intake by women who do not practice restrained eating re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:45:30Z,,0,0,090000648239984c
FDA-2016-N-3389-0388,FDA,FDA-2016-N-3389,"02-320 Resistant starch type 4-enriched diet lowered blood cholesterols and improved body composition in a double blind cross-over intervention  re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:58:30Z,,0,0,090000648239984d
FDA-2016-N-3389-0287,FDA,FDA-2016-N-3389,"Reference 02-284 Combining wheat bran with resistant starch has more beneficial effects on fecal indexes than does wheat bran alone re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:40:58Z,,0,0,0900006482399ab4
FDA-2016-N-3389-0293,FDA,FDA-2016-N-3389,"Reference 02-290 Comparative study of the acute effects of resistant starch and dietary fibers on metabolic indexes in men re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:41:45Z,,0,0,0900006482399ac4
FDA-2016-N-3389-0314,FDA,FDA-2016-N-3389,"Reference 02-311 Evaluation of the effect of four fibers on laxation, gastrointestinal tolerance and serum markers in healthy humans re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:44:34Z,,0,0,0900006482399afd
FDA-2016-N-3389-0365,FDA,FDA-2016-N-3389,"Reference 02-364 Blood glucose response to pea fiber comparisons with sugar beet fiber and wheat bran re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:51:33Z,,0,0,0900006482399bb0
FDA-2016-N-3389-0376,FDA,FDA-2016-N-3389,"Reference 02-375 A novel source of wheat fiber and protein effects on fecal bulk and serum lipids re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:56:07Z,,0,0,0900006482399bc4
FDA-2016-N-3389-0378,FDA,FDA-2016-N-3389,"Reference 02-377 The dietary effects of xanthan gum in man re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:57:14Z,,0,0,0900006482399bc6
FDA-2016-N-3389-0029,FDA,FDA-2016-N-3389,"Reference 02-26 Effects of a combination fiber system on appetite and energy intake in overweight humans re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T17:57:44Z,,0,0,09000064823993ec
FDA-2016-N-3389-0061,FDA,FDA-2016-N-3389,"Reference 02-57 Galactooligosacchraide supplementation reduces stress-induced gastrointestinal dysfunction and days of cold or flu a randomized, double-blind, controlled trial re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:04:28Z,,0,0,090000648239941e
FDA-2016-N-3389-0086,FDA,FDA-2016-N-3389,"Reference 02-82 The effects of oligofructose on metabolic control parameters in type-2 diabetes. re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:07:45Z,,0,0,090000648239943c
FDA-2016-N-3389-0002,FDA,FDA-2016-N-3389,Scientific Evaluation of the Evidence on the Beneficial Physiological Effects of Isolated or Synthetic Non-digestible Carbohydrates Submitted as a Citizen Petition (21 CFR 10.30): Guidance for Industry,Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T16:03:01Z,,0,0,09000064823bc576
FDA-2016-N-3389-0051,FDA,FDA-2016-N-3389,"Reference 02-47 Therapeutic effects of marine collagen peptides on re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:02:47Z,,0,0,0900006482399511
FDA-2016-N-3389-0067,FDA,FDA-2016-N-3389,"Reference 02-63 A mixture of trans-galactooligosaccharides reduced markers of metabolic syndrome and modulates the fecal microbiota and immune function of overweight adults. re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:05:15Z,,0,0,0900006482399543
FDA-2016-N-3389-0071,FDA,FDA-2016-N-3389,"Reference 02-67 Short-term effect of bedtime consumption of fermented milk supplemented with calcium, inulin-type fructans and caseinphosphopetides on bone metabolism re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:05:43Z,,0,0,0900006482399547
FDA-2016-N-3389-0073,FDA,FDA-2016-N-3389,"Reference 02-69 Bacterial fermentation of fructooligosaccharides and resistant starch in patients with an ileal pouch-anal anastomosis re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:06:01Z,,0,0,090000648239955c
FDA-2016-N-3389-0104,FDA,FDA-2016-N-3389,"Reference 02-100 Insight into the prebiotic concept lessons from an exploratory, double blind intervention study with inulin type fructans in obese women re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:10:37Z,,0,0,09000064823995a8
FDA-2016-N-3389-0237,FDA,FDA-2016-N-3389,"Reference 02-234 Polydextrose its impact on short-term food intake and subjective feelings of satiety in males – a randomized controlled cross-over study re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:32:42Z,,0,0,0900006482399a30
FDA-2016-N-3389-0249,FDA,FDA-2016-N-3389,"Reference 02-246 Digestions and physiological properties of resistant starch in the human large bowel re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:34:27Z,,0,0,0900006482399a51
FDA-2016-N-3389-0229,FDA,FDA-2016-N-3389,"Reference 02-226 Studies on the effects of polydextrose intake on physiologic functions in Chinese people re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:30:43Z,,0,0,09000064823997ae
FDA-2016-N-3389-0235,FDA,FDA-2016-N-3389,"Reference 02-232 Postprandial effects of polydextrose on satiety hormone responses and subjective feelings of appetite in obese participants re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:32:17Z,,0,0,09000064823997b4
FDA-2016-N-3389-0267,FDA,FDA-2016-N-3389,"Reference 02-264 Food amylose content affects postprandial glucose and insulin responses re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:37:57Z,,0,0,09000064823997dc
FDA-2016-N-3389-0306,FDA,FDA-2016-N-3389,"Reference 02-303 Gastrointestinal effects of resistant starch, soluble maize fibre and pullulan in healthy adults re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:43:34Z,,0,0,0900006482399825
FDA-2016-N-3389-0326,FDA,FDA-2016-N-3389,"Reference 02-324 Evaluation of digestive tolerance of a soluble corn fibre re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:46:15Z,,0,0,0900006482399851
FDA-2016-N-3389-0291,FDA,FDA-2016-N-3389,"Reference 02-288 Effect of resistant starch on fecal bulk and fermentation-dependent events in humans re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:41:26Z,,0,0,0900006482399ac2
FDA-2016-N-3389-0303,FDA,FDA-2016-N-3389,"Reference 02-300  Dietary Reference Intakes Proposed Definition of Dietary Fiber re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:43:12Z,,0,0,0900006482399ad6
FDA-2016-N-3389-0319,FDA,FDA-2016-N-3389,"Reference 02-316 Slowly digestible waxy maize starch prepared by octenyl succinic anhydride esterification and heat – moisture treatment glycemic response and mechanism re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:45:08Z,,0,0,0900006482399b06
FDA-2016-N-3389-0366,FDA,FDA-2016-N-3389,"Reference 02-365 Metabolic effects and clinical value of beet fiber treatment in NIDDM patients re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:51:41Z,,0,0,0900006482399bb1
FDA-2016-N-3389-0368,FDA,FDA-2016-N-3389,"Reference 02-367 Gastrointestinal effects of sugarbeet fiber and wheat bran in healthy men re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:51:54Z,,0,0,0900006482399bb3
FDA-2016-N-3389-0369,FDA,FDA-2016-N-3389,"Reference 02-368 Sugar beet fiber in formula diet reduces postprandial blood glucose, serum insulin and serum hydroxyproline re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:51:59Z,,0,0,0900006482399bb4
FDA-2016-N-3389-0060,FDA,FDA-2016-N-3389,"Reference 02-56 Transgalactooligosaccharides stimulate calcium absorption in postmenopausal women. re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:04:20Z,,0,0,090000648239941d
FDA-2016-N-3389-0040,FDA,FDA-2016-N-3389,"Reference 02-36 Inclusion of guar gum and alginate into a crispy bar improves postprandial glycemia in human re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:00:28Z,,0,0,0900006482399502
FDA-2016-N-3389-0005,FDA,FDA-2016-N-3389,"Reference 02-02 Supplementation with gum arabic fiber increases fecal nitrogen excretion and lowers serum urea nitrogen concentration in chronic renal failure patients re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T17:52:10Z,,0,0,0900006482399037
FDA-2016-N-3389-0013,FDA,FDA-2016-N-3389,"Reference 02-10 Long-term effects of water-soluble dietary fiber in the management of hypercholesterolemia in healthy men and women re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T17:53:36Z,,0,0,09000064823993b1
FDA-2016-N-3389-0016,FDA,FDA-2016-N-3389,"Reference 02-13 Hypocholesterolemic effect of gum acacia in men re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T17:54:04Z,,0,0,09000064823993b4
FDA-2016-N-3389-0056,FDA,FDA-2016-N-3389,"Reference 02-52 Effects of cottonseed dietary fiber on metabolic parameters in diabetic rats and non-insulin dependent diabetic humans re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:03:49Z,,0,0,0900006482399418
FDA-2016-N-3389-0062,FDA,FDA-2016-N-3389,"Reference 02-58 Effects of administration of galactooliogaccharides on human faecal microflora, stool weight and abdominal sensation re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:04:39Z,,0,0,090000648239941f
FDA-2016-N-3389-0043,FDA,FDA-2016-N-3389,"Reference 02-39 Apple fiber and gum arabic lowers total and Low-density lipoprotein cholesterol levels in men with mild hypercholesterolemia re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:00:51Z,,0,0,0900006482399505
FDA-2016-N-3389-0128,FDA,FDA-2016-N-3389,"Reference 02-125 Efficacy of inulin enriched yogurt on bowel habits in patients with irritable bowel syndrome with constipation a pilot study re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:14:56Z,,0,0,0900006482399686
FDA-2016-N-3389-0133,FDA,FDA-2016-N-3389,"Reference 02-130 The effect of chicory fructan fiber on calcium absorption and bone metabolism in Korean postmenopausal women re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:15:27Z,,0,0,0900006482399691
FDA-2016-N-3389-0139,FDA,FDA-2016-N-3389,"Reference 02-136 Addition of inulin to a moderately high-carbohydrate diet reduces hepatic lipogenesis and plasma triacylglycerol concentrations in humans re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:16:18Z,,0,0,0900006482399699
FDA-2016-N-3389-0190,FDA,FDA-2016-N-3389,"Reference 02-187 The effect on the blood lipid profile of soy foods combined with a prebiotic a randomized controlled trial re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:25:04Z,,0,0,090000648239973a
FDA-2016-N-3389-0194,FDA,FDA-2016-N-3389,"Reference 02-191 Blood lipids and lipoproteins in adult men fed four refined fibers re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:25:40Z,,0,0,0900006482399741
FDA-2016-N-3389-0198,FDA,FDA-2016-N-3389,"Reference 02-195 Physiochemical properties of karaya gum re Evaluation of the Beneficial Physiological Effects of Isolated or Synthetic Non-Digestible Carbohydrates; Request for Scientific Data, Information, and Comments",Supporting & Related Material,Background Material,2016-11-23T05:00:00Z,2016,11,,,2016-11-23T18:26:10Z,,0,0,0900006482399745